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Submit ReviewStressin I
Description: CRF1 agonist
Alternative Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31,Lys34]Ac-hCRF (4-41)
Purity: ≥95% (HPLC)
Biological Activity for Stressin I
Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
Licensing Information
Sold with the permission of the SALK Institute
Technical Data for Stressin I
| M. Wt | 4472.24 |
| Formula | C203H337N57O56 |
| Sequence |
PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 935739-46-1 |
| PubChem ID | 90479815 |
| InChI Key | HZKFMBAUDWRPRY-WNBAZHKDSA-N |
| Smiles | CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Stressin I
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Stressin I
References for Stressin I
References are publications that support the biological activity of the product.
Rivier et al (2007) Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668 PMID: 17335188
Rivier et al (2002) Receptor-selective cortico. releasing factor analogs. Endocrin.Soc.Abstr. P2-50
Bruchas et al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528 PMID: 20052275
If you know of a relevant reference for Stressin I, please let us know.
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Keywords: Stressin I, Stressin I supplier, CRF1, agonists, Corticotropin-Releasing, Factor1, Receptors, Factor, StressinI, cyclo(31-34)[D-Phe12,Nle21,38,Glu31,, Lys34]Ac-hCRF, (4-41), 1608, Tocris Bioscience
2 Citations for Stressin I
Citations are publications that use Tocris products. Selected citations for Stressin I include:
Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology 70 316 PMID: 23470280
Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407 PMID: 18184783
Do you know of a great paper that uses Stressin I from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.