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Submit Review8-Azaadenosine
Description: ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Chemical Name: 3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
Purity: ≥98% (HPLC)
Biological Activity for 8-Azaadenosine
8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
Compound Libraries for 8-Azaadenosine
8-Azaadenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 8-Azaadenosine
| M. Wt | 268.23 |
| Formula | C9H12N6O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 10299-44-2 |
| PubChem ID | 96410 |
| InChI Key | OAUKGFJQZRGECT-UUOKFMHZSA-N |
| Smiles | NC1=NC=NC2=C1N=NN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 8-Azaadenosine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.82 | 100 |
Preparing Stock Solutions for 8-Azaadenosine
The following data is based on the product molecular weight 268.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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Product Datasheets for 8-Azaadenosine
References for 8-Azaadenosine
References are publications that support the biological activity of the product.
Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID: 27292188
Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID: 27494666
If you know of a relevant reference for 8-Azaadenosine, please let us know.
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Keywords: 8-Azaadenosine, 8-Azaadenosine supplier, ADAR1, adenosine, deaminases, acting, on, double-stranded, RNA, dsRNA, leukemia, stem, cells, LSC, self-renewal, inhibitors, inhibits, Deaminases, Cancer, Stem, Cells, 6868, Tocris Bioscience
Citations for 8-Azaadenosine
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