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MK 1903

Cat. No. 4622 4 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective GPR109A (HCA2) agonist
Chemical Name: (4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MK 1903

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

Compound Libraries for MK 1903

MK 1903 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MK 1903

M. Wt 164.16
Formula C8H8N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1268882-43-4
PubChem ID 49763030
InChI Key CUTZNERBKDMLAP-QWWZWVQMSA-N
Smiles [H][C@@]12CC3=C(NN=C3C(O)=O)[C@@]([H])1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MK 1903

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.42 100
ethanol 8.21 50

Preparing Stock Solutions for MK 1903

The following data is based on the product molecular weight 164.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.46 mL 60.92 mL
5 mM 1.22 mL 6.09 mL 12.18 mL
10 mM 0.61 mL 3.05 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets for MK 1903

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for MK 1903

References are publications that support the biological activity of the product.

Boatman (2012) (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J.Med.Chem. 55 3644 PMID: 22435740

Lauring (2012) Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci.Transl.Med. 4 148ra115 PMID: 22914621

If you know of a relevant reference for MK 1903, please let us know.

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Keywords: MK 1903, MK 1903 supplier, MK1903, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, agonists, Hydroxycarboxylic, Acid, Receptors, 4622, Tocris Bioscience

4 Citations for MK 1903

Citations are publications that use Tocris products. Selected citations for MK 1903 include:

Perrone et al (2023) Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) Neuropharmacology PMID: 36796675

Elisabetta et al (2023) Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. EMBO Mol Med 15 e16225 PMID: 36594243

Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249

Marinelli et al (2019) Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells Sci.Rep. 9 643 PMID: 30679727

Do you know of a great paper that uses MK 1903 from Tocris? Please let us know.

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