Lactate Dehydrogenase A

Products

Background

Literature (2)

Gene Data

Lactate Dehydrogenase A Inhibitors
Cat. No.	Product Name / Activity
4795	Galloflavin
	Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
5189	GSK 2837808A
	Potent and selective LDHA inhibitor
5363	NHI 2
	LDHA inhibitor

Related Targets

Hypoxia Inducible Factors (HIF)

Oxidative Phosphorylation

Lactate Dehydrogenase A (LDHA; LDH5), EC 1.1.1.27, is one of five isoforms of the lactate dehydrogenase family. It catalyzes the conversion of pyruvate to lactate under anaerobic conditions and plays a key role in the altered glycolytic metabolism that is a feature of cancer cells. LDHs are tetrameric enzymes comprising two different types of subunit, M and H; different combinations of these subunits result in five separate isoforms. LDHA, which is found mainly in skeletal muscle but also in tumors, consists of four M subunits.

LDHA is overexpressed in a wide range of tumors and is associated with the more aggressive cancer phenotypes and poor prognosis. Expression of LDHA is regulated by hypoxia inducible factor-1 (HIF-1) and the oncogene c-Myc. The enzyme is necessary for tumor maintenance, since cancer cells rely on glycolytic metabolism for energy, whereas it is not essential for normal healthy cells that rely on oxidative phosphorylation. Inhibition of LDHA has been shown in animal models to reduce tumor growth, increase oxidative stress and induce apoptosis. The enzyme is therefore being evaluated as a therapeutic target in cancer metabolism.

External sources of pharmacological information for Lactate Dehydrogenase A :

BJP Guide

Literature for Lactate Dehydrogenase A

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Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Glycolysis
Tricarboxylic Acid Cycle
Lipidogenesis
1C Metabolism and Nucleic Acid Synthesis
Drivers of Metabolic Reprogramming
pH and Redox Balance

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.