Home / Pharmacology / Enzymes / Dehydrogenases / Lactate Dehydrogenase A / Lactate Dehydrogenase A Inhibitors / Galloflavin

Galloflavin

Cat. No. 4795 2 Citations 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
Chemical Name: 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Galloflavin

Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

Technical Data for Galloflavin

M. Wt 316.26
Formula C12H5O8K
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1780260-20-9
PubChem ID 90488971
InChI Key XSPGPNGPTLAWMC-UHFFFAOYSA-M
Smiles [K+].OC1=C(O)C(O)=C2C3=C(OC(=O)C2=C1)C=C([O-])C(=O)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Galloflavin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.58 5

Preparing Stock Solutions for Galloflavin

The following data is based on the product molecular weight 316.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 63.24 mL 316.2 mL 632.39 mL
0.25 mM 12.65 mL 63.24 mL 126.48 mL
0.5 mM 6.32 mL 31.62 mL 63.24 mL
2.5 mM 1.26 mL 6.32 mL 12.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Galloflavin

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Galloflavin

References are publications that support the biological activity of the product.

Manerba et al (2012) Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7 311 PMID: 22052811

Fiume et al (2013) Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 430 466 PMID: 23237800

Farabegoli et al (2012) Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 47 729 PMID: 22954722

If you know of a relevant reference for Galloflavin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Lactate Dehydrogenase A Inhibitors

Keywords: Galloflavin, Galloflavin supplier, lactate, dehydrogenases, LDH-A, LDH-B, LDH, inhibitors, inhibits, aerobic, glycolysis, Lactate, Dehydrogenase, A, 4795, Tocris Bioscience

2 Citations for Galloflavin

Citations are publications that use Tocris products. Selected citations for Galloflavin include:

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Dietmar et al (2020) Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells. Anticancer Res 40 153-160 PMID: 31892563

Do you know of a great paper that uses Galloflavin from Tocris? Please let us know.

Reviews for Galloflavin

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Galloflavin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

20 μM galloflavin

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.