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Submit ReviewAtrial natriuretic factor (1-28) (human, porcine) is an endogenous peptide produced by the heart; involved in blood pressure regulation. Produces natriuresis, diuresis and vasorelaxation in vivo.
M. Wt | 3080.46 |
Formula | C127H205N45O39S3 |
Sequence |
SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Modifications: Disulfide bridge: 7-23) |
Storage | Store at -20°C |
Purity | ≥95% (HPLC) |
CAS Number | 91917-63-4 |
PubChem ID | 16129708 |
InChI Key | NSQLIUXCMFBZME-MPVJKSABSA-N |
Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility | Soluble to 1 mg/ml in water |
References are publications that support the biological activity of the product.
Atlas et al (1985) Atrial natriuretic factor (auriculin): structure and biological effects. J.Clin.Hypertens. 1 187 PMID: 2941526
de Bold et al (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230 767 PMID: 2932797
Rubattu and Volpe (2001) The atrial natriuretic peptide: a changing view. J.Hypertens. 19 1923 PMID: 11677356
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Keywords: Atrial Natriuretic Factor (1-28) (human, porcine), Atrial Natriuretic Factor (1-28) (human, porcine) supplier, Endogenous, peptide, regulating, blood, pressure, ANP, Receptors, Atrial, Natriuretic, Peptide, NPR, agonists, (1-28), (human,, porcine), Receptor, 1906, Tocris Bioscience
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Used in vitro to investigate different roles of NP family members.