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Submit Review(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
Description: Potent and selective sst2 agonist
Chemical Name: N-[(1R)-2-[[[(1S*,3R*)-3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4'-piperidine]-1'-carboxamide
Purity: ≥96% (HPLC)
Biological Activity for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).
Technical Data for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
| M. Wt | 539.71 |
| Formula | C33H41N5O2 |
| Storage | Store at +4°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 208706-12-1 |
| PubChem ID | 9915239 |
| InChI Key | DAMXHAMKVXERLM-FVBCXUTKSA-N |
| Smiles | NC[C@H]1CCC[C@@H](CNC([C@H](NC(N4CCC5(C(C=CC=C6)=C6C=C5)CC4)=O)CC2=CNC3=C2C=CC=C3)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
References for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
References are publications that support the biological activity of the product.
Yang et al (1998) Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J.Med.Chem. 41 2175 PMID: 9632348
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Keywords: (1R,1S,3R/1R,1R,3'S)-L-054,264, (1R,1S,3R/1R,1R,3'S)-L-054,264 supplier, Potent, selective, sst2, agonists, sst, Receptors, Somatostatin, (1R,1S,3R/1R,1R,3S)-L-054,264, L054264, 2444, Tocris Bioscience
Citations for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
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