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Submit Review2-Furoyl-LIGRLO-amide
Description: Potent and selective PAR2 agonist
Purity: ≥95% (HPLC)
Biological Activity for 2-Furoyl-LIGRLO-amide
2-Furoyl-LIGRLO-amide is a potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
Technical Data for 2-Furoyl-LIGRLO-amide
| M. Wt | 777.96 |
| Formula | C36H63N11O8 |
| Sequence |
LIGRLX (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 729589-58-6 |
| PubChem ID | 10395438 |
| InChI Key | OSKIRYSKGDEIOG-WTWMNNMUSA-N |
| Smiles | [H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-Furoyl-LIGRLO-amide
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for 2-Furoyl-LIGRLO-amide
References for 2-Furoyl-LIGRLO-amide
References are publications that support the biological activity of the product.
McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230
Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236
Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682
If you know of a relevant reference for 2-Furoyl-LIGRLO-amide, please let us know.
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Keywords: 2-Furoyl-LIGRLO-amide, 2-Furoyl-LIGRLO-amide supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, 3015, Tocris Bioscience
3 Citations for 2-Furoyl-LIGRLO-amide
Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:
Oe et al (2019) Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Sci.Rep. 9 2986 PMID: 30814628
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155
Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346 PMID: 24469043
Do you know of a great paper that uses 2-Furoyl-LIGRLO-amide from Tocris? Please let us know.
Reviews for 2-Furoyl-LIGRLO-amide
Average Rating: 5 (Based on 1 Review.)
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Potent PAR2 Agonist,.
By
Anonymous on 09/20/2019
Assay Type: Ex Vivo
Species: Mouse
ex-vivo mouse colonic tissue
Used this compound on an ex-vivo experiment. Tissue: Mouse colon.2F caused massive PAR2 receptor internalization in the colonic mucosa.Very easy to dissolve, great and potent PAR2 Agonist.