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Submit Review2-Methyl-5-hydroxytryptamine hydrochloride
Description: 5-HT3 agonist/potent 5-HT6 ligand
Purity: ≥98% (HPLC)
Biological Activity
5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).
Technical Data
| M. Wt | 226.71 |
| Formula | C11H14N2O.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 845861-49-6 |
| PubChem ID | 11492320 |
| InChI Key | ZNVRHQPXSBWLQP-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(CCN)C2=CC(O)=CC=C2N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9 PMID: 2402303
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755 PMID: 2299641
Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974
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Keywords: 2-Methyl-5-hydroxytryptamine hydrochloride, 2-Methyl-5-hydroxytryptamine hydrochloride supplier, 5-HT3, agonists, potent, 5-HT6, ligand, Serotonin, Receptors, 2-Me-5HT, 2, methyl5HT, 0558, Tocris Bioscience
Citations for 2-Methyl-5-hydroxytryptamine hydrochloride
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Currently there are no citations for 2-Methyl-5-hydroxytryptamine hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.