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Submit Review2-Palmitoylglycerol
Description: Endogenous lipid; enhances activity of 2-arachidonylglycerol (Cat. No. 1298)
Alternative Names: 2-Palm-Gl,2-PG
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Biological Activity for 2-Palmitoylglycerol
2-Palmitoylglycerol is a endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
Technical Data for 2-Palmitoylglycerol
| M. Wt | 330.51 |
| Formula | C19H38O4 |
| Storage | Store at -20°C |
| CAS Number | 23470-00-0 |
| PubChem ID | 123409 |
| InChI Key | BBNYCLAREVXOSG-UHFFFAOYSA-N |
| Smiles | OCC(CO)OC(CCCCCCCCCCCCCCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 2-Palmitoylglycerol
References for 2-Palmitoylglycerol
References are publications that support the biological activity of the product.
Ben-Shabat et al (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 353 23 PMID: 9721036
Gallily et al (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 406 R5 PMID: 11011050
Walker et al (2002) Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 121 159 PMID: 12505698
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Keywords: 2-Palmitoylglycerol, 2-Palmitoylglycerol supplier, Endogenous, lipid, enhances, activity, 2-AG, cannabinoid, receptors, fatty, acid, glycerol, ester, 2-arachidonylglycerol, 2-Palm-Gl, 2-PG, Other, Cannabinoids, 2206, Tocris Bioscience
Citations for 2-Palmitoylglycerol
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Currently there are no citations for 2-Palmitoylglycerol.
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.