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3-AP

Cat. No. 5962 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

5962 has been discontinued.

View all Ribonucleotide Reductase products.
Description: Ribonucleotide reductase inhibitor; also an iron chelator
Alternative Names: 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for 3-AP

3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

Technical Data for 3-AP

M. Wt 195.24
Formula C7H9N5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 143621-35-6
PubChem ID 9571836
InChI Key XMYKNCNAZKMVQN-NYYWCZLTSA-N
Smiles NC(N/N=C/C1=C(C=CC=N1)N)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for 3-AP

References are publications that support the biological activity of the product.

Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204 PMID: 24486217

Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3 PMID: 10470363

Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672 PMID: 1433178

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Keywords: 3-AP, 3-AP supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, 3-aminopyridine-2-carboxaldehyde, thiosemicarbazone, Reductase, DNA,, RNA, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 5962, Tocris Bioscience

1 Citation for 3-AP

Citations are publications that use Tocris products. Selected citations for 3-AP include:

Chitambar et al (2013) Iron-targeting antitumor activity of gal. compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956 PMID: 22900955

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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