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Submit Review3-AQC
Description: 5-HT3 antagonist
Chemical Name: 3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
Biological Activity for 3-AQC
3-AQC is a competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.
Technical Data for 3-AQC
| M. Wt | 395.42 |
| Formula | C16H17N5.C4H4O4 |
| Storage | Desiccate at -20°C |
| CAS Number | 201216-42-4 |
| PubChem ID | 11567402 |
| InChI Key | UHLVYEOCPBNJNA-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.C=CCN1CCN(CC1)C1=NC2=CC=CC=C2N=C1C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-AQC
References for 3-AQC
References are publications that support the biological activity of the product.
Buznikov et al (2005) The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 30 825 PMID: 16187217
Durk et al (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 17 599 PMID: 15802305
Monge et al (1993) Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 36 2745 PMID: 8410988
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Keywords: 3-AQC, 3-AQC supplier, 5-HT3, antagonists, Serotonin, Receptors, 0666, Tocris Bioscience
Citations for 3-AQC
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Currently there are no citations for 3-AQC.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.