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3-Bromocytisine

Cat. No. 3549 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent α4β4, α4β2 and α7 nAChR agonist
Chemical Name: (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 3-Bromocytisine

3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively).

Technical Data for 3-Bromocytisine

M. Wt 269.14
Formula C11H13BrN2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 207390-14-5
PubChem ID 15519735
InChI Key DWDCLEHDNICBMI-JGVFFNPUSA-N
Smiles O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3-Bromocytisine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.91 100
DMSO 26.91 100

Preparing Stock Solutions for 3-Bromocytisine

The following data is based on the product molecular weight 269.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.16 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for 3-Bromocytisine

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for 3-Bromocytisine

References are publications that support the biological activity of the product.

Houlihan et al (2001) Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem. 78 1029 PMID: 11553677

Moroni et al (2006) α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol. 70 755 PMID: 16720757

If you know of a relevant reference for 3-Bromocytisine, please let us know.

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Keywords: 3-Bromocytisine, 3-Bromocytisine supplier, 3-Br-Cytisine, nACh, receptor, agonist, nicotinic, acetylcholine, receptors, a4b4, a4b2, a7, agonists, alpha4beta4, alpha4beta2, alpha7, Nicotinic, (a4b2), Receptors, (Other, Subtypes), (a7), (Non-selective), 3549, Tocris Bioscience

1 Citation for 3-Bromocytisine

Citations are publications that use Tocris products. Selected citations for 3-Bromocytisine include:

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328

Do you know of a great paper that uses 3-Bromocytisine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.