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Description: Dopamine uptake inhibitor
Chemical Name: 3α-[(4-Chlorophenyl)phenylmethoxy] tropane hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for 3-CPMT
This cocaine analog binds with high affinity to the dopamine transporter (Ki = 30 nM) and blocks re-uptake of dopamine. However, it is a weak psychomotor stimulant and does not substitute for cocaine in addicted rats.
Technical Data for 3-CPMT
| M. Wt | 378.34 |
| Formula | C21H24ClNO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 14008-79-8 |
| PubChem ID | 203135 |
| InChI Key | FXKCQWIUITUJFU-UHFFFAOYSA-N |
| Smiles | Cl.CN1C2CCC1CC(C2)OC(C1=CC=CC=C1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-CPMT
References for 3-CPMT
References are publications that support the biological activity of the product.
Newman et al (1994) Novel 3α-(diphenylmethoxy)tropane analogs: potent DA uptake inhibitors without cocaine-like behavioural profiles. J.Med.Chem. 37 2258 PMID: 8057273
Newman et al (1995) Novel 4'-substituted and 4'4"-disubstituted 3α-(diphenylmethoxy)tropane analogs as potent and selective DA uptake inhibitors. J.Med.Chem. 38 3933 PMID: 7562926
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Keywords: 3-CPMT, 3-CPMT supplier, Dopamine, reuptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, 0917, Tocris Bioscience
Citations for 3-CPMT
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Currently there are no citations for 3-CPMT.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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