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Description: PARP inhibitor
Chemical Name: 4-(1H)-Quinazolinone
Purity: ≥99% (HPLC)
Biological Activity for 4-HQN
Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.
Technical Data for 4-HQN
| M. Wt | 146.15 |
| Formula | C8H6N2O |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 491-36-1 |
| PubChem ID | 63112 |
| InChI Key | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
| Smiles | OC1=C2C=CC=CC2=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4-HQN
References for 4-HQN
References are publications that support the biological activity of the product.
Banasik et al (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 267 1569 PMID: 1530940
Halmosi et al (2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 59 1497 PMID: 11353811
Veres et al (2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 310 247 PMID: 14999056
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Keywords: 4-HQN, 4-HQN supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, Poly(ADP-ribose), 2192, Tocris Bioscience
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