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Description: Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Chemical Name: 4-Iodo-6-phenylpyrimidine
Purity: ≥98% (HPLC)
Biological Activity for 4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
Technical Data for 4-IPP
| M. Wt | 282.08 |
| Formula | C10H7IN2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 41270-96-6 |
| PubChem ID | 817368 |
| InChI Key | ZTCJXHNJVLUUMR-UHFFFAOYSA-N |
| Smiles | IC1=NC=NC(C2=CC=CC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4-IPP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.21 | 100 | |
| ethanol | 14.1 | 50 |
Preparing Stock Solutions for 4-IPP
The following data is based on the product molecular weight 282.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.55 mL | 17.73 mL | 35.45 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets for 4-IPP
References for 4-IPP
References are publications that support the biological activity of the product.
Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253 PMID: 18794110
If you know of a relevant reference for 4-IPP, please let us know.
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Keywords: 4-IPP, 4-IPP supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, inhibits, suicide, substrates, cytokines, 4IPP, Cytokines, 3429, Tocris Bioscience
4 Citations for 4-IPP
Citations are publications that use Tocris products. Selected citations for 4-IPP include:
Justin D et al (2020) Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression. Front Immunol 11 1191 PMID: 32625208
Subbannayya et al (2015) Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. J Biol Chem 15 843 PMID: 26530123
Salazar et al (2014) The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer 13 198 PMID: 25168820
Takahashi et al (2013) Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses. PLoS One 8 e78250 PMID: 24167613
Do you know of a great paper that uses 4-IPP from Tocris? Please let us know.
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