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Submit Review5'-Fluoroindirubinoxime
Description: FLT3 inhibitor; displays antiproliferative activity
Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Purity: ≥99% (HPLC)
Biological Activity for 5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
Licensing Information
Sold under licence from Anygen Co. Ltd.
Technical Data for 5'-Fluoroindirubinoxime
| M. Wt | 295.27 |
| Formula | C16H10FN3O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 861214-33-7 |
| PubChem ID | 11580208 |
| InChI Key | LBUXOYSDWHGJNP-UHFFFAOYSA-N |
| Smiles | O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 5'-Fluoroindirubinoxime
References for 5'-Fluoroindirubinoxime
References are publications that support the biological activity of the product.
Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253 PMID: 17200363
Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466 PMID: 18824607
Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033 PMID: 20153646
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Keywords: 5'-Fluoroindirubinoxime, 5'-Fluoroindirubinoxime supplier, FMS-like, receptor, tyrosine, kinase-3, FLT3, inhibitors, inhibits, antiproliferative, 5-Fluoroindirubinoxime, 4033, Tocris Bioscience
Citations for 5'-Fluoroindirubinoxime
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