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Submit Review6-Iodonordihydrocapsaicin
Description: Potent, competitive vanilloid receptor antagonist
Purity: ≥99% (HPLC)
Biological Activity for 6-Iodonordihydrocapsaicin
Potent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.
Technical Data for 6-Iodonordihydrocapsaicin
| M. Wt | 419.3 |
| Formula | C17H26INO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 859171-97-4 |
| PubChem ID | 5149140 |
| InChI Key | AAORACFZMYMFCG-UHFFFAOYSA-N |
| Smiles | CCCCCCCCC(=O)NCC1=CC(OC)=C(O)C=C1I |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 6-Iodonordihydrocapsaicin
References for 6-Iodonordihydrocapsaicin
References are publications that support the biological activity of the product.
Appendino et al (2003) Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br.J.Pharmacol. 139 1417 PMID: 12922928
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Keywords: 6-Iodonordihydrocapsaicin, 6-Iodonordihydrocapsaicin supplier, Potent, competitive, vanilloids, receptors, antagonists, VR1, TRPV, Channels, Transient, Receptor, Potential, 1975, Tocris Bioscience
1 Citation for 6-Iodonordihydrocapsaicin
Citations are publications that use Tocris products. Selected citations for 6-Iodonordihydrocapsaicin include:
Kaji et al (2011) Effects of luminal thymol on epithelial transport in human and rat colon. Am J Physiol Gastrointest Liver Physiol 300 G1132 PMID: 21372164
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