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Submit Review8-Bromo-cGMP, sodium salt is a membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
M. Wt | 446.09 |
Formula | C10H10BrN5NaO7P |
Storage | Desiccate at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 51116-01-9 |
PubChem ID | 23702959 |
InChI Key | ZJRFCXHKYQVNFK-YEOHUATISA-M |
Smiles | [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 44.61 | 100 |
The following data is based on the product molecular weight 446.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.24 mL | 11.21 mL | 22.42 mL |
5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
References are publications that support the biological activity of the product.
Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361 PMID: 1665733
Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210 PMID: 4359834
Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103 PMID: 1321950
If you know of a relevant reference for 8-Bromo-cGMP, sodium salt, please let us know.
Keywords: 8-Bromo-cGMP, sodium salt, 8-Bromo-cGMP, sodium salt supplier, cGMP, analog, activates, PKG, protein, kinase, G, activator, Heterotrimeric, G-protein, GTPases, Protein, Kinase, 1089, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for 8-Bromo-cGMP, sodium salt include:
Capuano et al (2009) Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology. Mol Pain 5 43 PMID: 19660121
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Foster et al (2014) Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol 111 659 PMID: 24259545
Do you know of a great paper that uses 8-Bromo-cGMP, sodium salt from Tocris? Please let us know.
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