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A 1899

Cat. No. 6972 Submit a Review Datasheet / COA / SDS
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Description: Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
Chemical Name: N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for A 1899

A 1899 is a potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

Compound Libraries for A 1899

A 1899 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 1899

M. Wt 500.55
Formula C30H26F2N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 498577-46-1
PubChem ID 9827303
InChI Key IXKPEYHRIVQTCU-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)CC(NCC2=C(C3=C(C(NCC4=C(C=C(C=C4)F)F)=O)C=CC=C3)C=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 1899

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.05 100

Preparing Stock Solutions for A 1899

The following data is based on the product molecular weight 500.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for A 1899

References are publications that support the biological activity of the product.

Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID: 21362619

If you know of a relevant reference for A 1899, please let us know.

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