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Submit ReviewA 582941
Description: α7 nAChR partial agonist
Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
Purity: ≥98% (HPLC)
Biological Activity for A 582941
A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).
Technical Data for A 582941
| M. Wt | 280.37 |
| Formula | C17H20N4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 848591-90-2 |
| PubChem ID | 44190553 |
| InChI Key | GTMRUYCIJSNXGB-GASCZTMLSA-N |
| Smiles | [H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 582941
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.04 | 100 | |
| 1eq. HCl | 14.02 | 50 |
Preparing Stock Solutions for A 582941
The following data is based on the product molecular weight 280.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.57 mL | 17.83 mL | 35.67 mL |
| 5 mM | 0.71 mL | 3.57 mL | 7.13 mL |
| 10 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
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Product Datasheets for A 582941
References for A 582941
References are publications that support the biological activity of the product.
Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 324 179 PMID: 17959745
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Keywords: A 582941, A 582941 supplier, A582941, selective, alpha7, α7, a7, nicotinics, receptors, partial, agonists, Nicotinic, (a7), Receptors, 4341, Tocris Bioscience
Citations for A 582941
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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