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Submit ReviewA 784168
Description: Potent and selective TRPV1 antagonist
Chemical Name: 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for A 784168
A 784168 is a potent TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors.
Compound Libraries for A 784168
A 784168 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for A 784168
| M. Wt | 479.4 |
| Formula | C19H15F6N3O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 824982-41-4 |
| PubChem ID | 11420211 |
| InChI Key | SDUAWRFBHRAFBM-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3)C(CC2)=CCN2C1=C(C(F)(F)F)C=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 784168
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.94 | 100 | |
| ethanol | 23.97 | 50 |
Preparing Stock Solutions for A 784168
The following data is based on the product molecular weight 479.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.43 mL | 20.86 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for A 784168
References for A 784168
References are publications that support the biological activity of the product.
Bianchi et al (2007) [3H]-A-778317 [1-((R-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 323 285 PMID: 17660385
Cui et al (2006) TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J.Neurosci. 26 9385 PMID: 16971522
If you know of a relevant reference for A 784168, please let us know.
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Keywords: A 784168, A 784168 supplier, A784168, trpv1, transient, receptor, potential, vanilloids, antagonists, potent, selective, TRPV, 4319, Tocris Bioscience
2 Citations for A 784168
Citations are publications that use Tocris products. Selected citations for A 784168 include:
Alharris et al (2019) Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget 10 45 PMID: 30713602
James et al (2022) Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels. Nat Commun 13 600 PMID: 35140203
Do you know of a great paper that uses A 784168 from Tocris? Please let us know.
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