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Submit ReviewA 844606
Discontinued Product
4477 has been discontinued.
Description: Selective α7 nAChR partial agonist
Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
Purity: ≥99% (HPLC)
Biological Activity for A 844606
A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.
Technical Data for A 844606
| M. Wt | 320.38 |
| Formula | C20H20N2O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 861119-08-6 |
| PubChem ID | 11461365 |
| InChI Key | WUJHMDPPANTBTQ-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C=CC(N4CC(CN(C)C5)C5C4)=C3)OC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 844606
References for A 844606
References are publications that support the biological activity of the product.
Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054 PMID: 18157163
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Keywords: A 844606, A 844606 supplier, A844606, nicotinic, acetylcholine, receptors, alpha7, a7, agonists, nAChR, α7, Nicotinic, (a7), Receptors, 4477, Tocris Bioscience
Citations for A 844606
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Currently there are no citations for A 844606.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.