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Submit ReviewA 867744
Description: Positive allosteric modulator of α7 nAChRs
Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
Purity: ≥97% (HPLC)
Biological Activity for A 867744
A 867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.
Technical Data for A 867744
| M. Wt | 402.89 |
| Formula | C20H19ClN2O3S |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1000279-69-5 |
| PubChem ID | 23642319 |
| InChI Key | ABACVOXFUHDKNZ-UHFFFAOYSA-N |
| Smiles | O=C(CC)C1=C(C)N(C3=CC=C(S(N)(=O)=O)C=C3)C(C2=CC=C(Cl)C=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 867744
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.29 | 100 | |
| ethanol | 4.03 | 10 with gentle warming |
Preparing Stock Solutions for A 867744
The following data is based on the product molecular weight 402.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.82 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for A 867744
References for A 867744
References are publications that support the biological activity of the product.
Malysz et al (2009) In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting J.Pharmacol.Exp.Ther. 330 257 PMID: 19389923
Faghih et al (2009) Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 28 3377 PMID: 19419141
If you know of a relevant reference for A 867744, please let us know.
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Keywords: A 867744, A 867744 supplier, A867744, positive, allosteric, modulators, a7, alpha7, acetylcholine, nicotinic, receptors, nAChRs, selective, PAM, Nicotinic, (a7), Receptors, 4571, Tocris Bioscience
Citations for A 867744
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Literature in this Area
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Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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