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Submit Reviewα-Conotoxin ImI
Discontinued Product
3119 has been discontinued.
Description: α7 and α9 selective nAChR antagonist
Biological Activity for α-Conotoxin ImI
Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.
Licensing Information
Sold under license from University of Utah
Technical Data for α-Conotoxin ImI
| M. Wt | 1351.6 |
| Formula | C52H78N20O15S4 |
| Sequence |
GCCSDPRCAWRC (Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12) |
| Storage | Store at -20°C |
| CAS Number | 156467-85-5 |
| PubChem ID | 76324742 |
| InChI Key | AIKMSOHWSGWCNX-VAYQAVKTSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for α-Conotoxin ImI
References for α-Conotoxin ImI
References are publications that support the biological activity of the product.
McIntosh et al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733 PMID: 8206995
Johnson et al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194 PMID: 7651351
Pereira et al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472 PMID: 8819535
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Keywords: alpha-conotoxin ImI, alpha-conotoxin ImI supplier, α7, alpha7, a7, α9, alpha9, a9, selective, nAChR, antagonists, Nicotinic, Receptors, Acetylcholine, Non-Selective, α-conotoxin, alpha-conotoxin, ImI, a-conotoxinImI, conotoxins, venoms, (a7), (Other, Subtypes), 3119, Tocris Bioscience
1 Citation for α-Conotoxin ImI
Citations are publications that use Tocris products. Selected citations for α-Conotoxin ImI include:
White et al (2016) Nicotine inhibits potassium currents in Aplysia bag cell neurons. J Neurophysiol 115 2635 PMID: 26864763
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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