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Submit Reviewα-MSH
Description: Endogenous melanocortin receptor agonist
Alternative Names: α-Melanotropin,α-Melanocyte-stimulating hormone
Purity: ≥95% (HPLC)
Biological Activity for α-MSH
α-MSH is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
Technical Data for α-MSH
| M. Wt | 1664.9 |
| Formula | C77H109N21O19S |
| Sequence |
SYSMEHFRWGKPV (Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 581-05-5 |
| PubChem ID | 16132144 |
| InChI Key | WHNFPRLDDSXQCL-UAZQEYIDSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-MSH
| Solubility | Soluble to 0.60 mg/ml in water |
Product Datasheets for α-MSH
References for α-MSH
References are publications that support the biological activity of the product.
Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757 PMID: 11792967
Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429 PMID: 16679696
If you know of a relevant reference for α-MSH, please let us know.
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Keywords: alpha-MSH, alpha-MSH supplier, Endogenous, melanocortin, receptor, agonists, MC, Receptors, Melanocortin, α-MSH, alpha-MSH, α-Melanocyte-stimulating, alpha-Melanocyte-stimulating, hormone, α-Melanotropin, alpha-Melanotropin, a-MSH, a-Melanotropin, a-Melanocyte-stimulating, 2584, Tocris Bioscience
2 Citations for α-MSH
Citations are publications that use Tocris products. Selected citations for α-MSH include:
Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Do you know of a great paper that uses α-MSH from Tocris? Please let us know.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.