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Submit Reviewα-Spinasterol
Description: TRPV1 antagonist; active in vivo
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Purity: ≥95% (HPLC)
Biological Activity for α-Spinasterol
α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
Technical Data for α-Spinasterol
| M. Wt | 412.69 |
| Formula | C29H48O |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 481-18-5 |
| PubChem ID | 5281331 |
| InChI Key | JZVFJDZBLUFKCA-FXIAWGAOSA-N |
| Smiles | C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for α-Spinasterol
References for α-Spinasterol
References are publications that support the biological activity of the product.
Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009
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Keywords: alpha-Spinasterol, alpha-Spinasterol supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable, TRPV, 4729, Tocris Bioscience
Citations for α-Spinasterol
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Currently there are no citations for α-Spinasterol.
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