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Submit ReviewAA 147
Description: ER proteostasis regulator
Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity: ≥98% (HPLC)
Biological Activity for AA 147
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
Compound Libraries for AA 147
AA 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AA 147
| M. Wt | 255.31 |
| Formula | C16H17NO2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 393121-74-9 |
| PubChem ID | 882909 |
| InChI Key | AWHLTHOHBAGPMY-UHFFFAOYSA-N |
| Smiles | CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AA 147
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.53 | 100 | |
| ethanol | 25.53 | 100 |
Preparing Stock Solutions for AA 147
The following data is based on the product molecular weight 255.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.58 mL | 39.17 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.83 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets for AA 147
References for AA 147
References are publications that support the biological activity of the product.
Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961
If you know of a relevant reference for AA 147, please let us know.
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Keywords: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience
5 Citations for AA 147
Citations are publications that use Tocris products. Selected citations for AA 147 include:
Yang et al (2021) Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Front Surg 8 665260 PMID: 34222317
Shu et al (2021) Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. J Am Heart Assoc 10 e020216 PMID: 34111943
Peng et al (2021) In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. Nat Metab 3 682-700 PMID: 34031592
Jochen H M et al (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun 14 2132 PMID: 37059720
Xiaoyan et al (2022) Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes. Nat Commun 13 5859 PMID: 36216837
Do you know of a great paper that uses AA 147 from Tocris? Please let us know.
Reviews for AA 147
Average Rating: 5 (Based on 1 Review.)
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ATF6 activation.
By
Anonymous on 10/30/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Molm13
Used to induce activation of the ATF6 ER stress pathway
Worked well, induced translocation of ATF to the nucleus (green in image), showing cleavage of the protein and its activation. Caused reduction of downstream inhibited genes CPT1a and PPARA in our experiments
