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Submit ReviewAA 2414
Description: Thromboxane A2 (TP) receptor antagonist
Alternative Names: Seratrodast
Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Purity: ≥98% (HPLC)
Biological Activity for AA 2414
AA 2414 is a thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.
Technical Data for AA 2414
| M. Wt | 354.44 |
| Formula | C22H26O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 112665-43-7 |
| PubChem ID | 2449 |
| InChI Key | ZBVKEHDGYSLCCC-UHFFFAOYSA-N |
| Smiles | O=C1C(C)=C(C)C(C(C(C2=CC=CC=C2)CCCCCC(O)=O)=C1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AA 2414
References for AA 2414
References are publications that support the biological activity of the product.
Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91 PMID: 2748922
Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383 PMID: 8019502
Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99 PMID: 17706964
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Keywords: AA 2414, AA 2414 supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Seratrodast, Receptors, 3025, Tocris Bioscience
1 Citation for AA 2414
Citations are publications that use Tocris products. Selected citations for AA 2414 include:
Hennenberg et al (2013) The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle. Am J Physiol Renal Physiol 305 F1383 PMID: 24049147
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