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Submit ReviewAbacavir hemisulfate
Description: Reverse transcriptase inhibitor; antiretroviral
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity: ≥99% (HPLC)
Biological Activity for Abacavir hemisulfate
Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.
Licensing Information
Sold for research purposes under agreement from Viiv.
Compound Libraries for Abacavir hemisulfate
Abacavir hemisulfate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Abacavir hemisulfate
| M. Wt | 335.37 |
| Formula | C14H18N6O.½H2SO4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 188062-50-2 |
| PubChem ID | 75539558 |
| InChI Key | WMHSRBZIJNQHKT-NHMRBCHTSA-N |
| Smiles | OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Abacavir hemisulfate
References for Abacavir hemisulfate
References are publications that support the biological activity of the product.
Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353 PMID: 22725138
Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912 PMID: 10720512
Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082 PMID: 9145874
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Keywords: Abacavir hemisulfate, Abacavir hemisulfate supplier, competitive, guanosine, analog, reverse, transcriptase, inhibitors, inhibits, HIV, replication, orally, active, brain, penetrant, antiretroviral, agents, DNA, Polymerase, 4148, Tocris Bioscience
1 Citation for Abacavir hemisulfate
Citations are publications that use Tocris products. Selected citations for Abacavir hemisulfate include:
Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.