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Submit ReviewABT 751
Description: Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for ABT 751
ABT 751 is an antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.
Technical Data for ABT 751
| M. Wt | 371.41 |
| Formula | C18H17N3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 141430-65-1 |
| PubChem ID | 3035714 |
| InChI Key | URCVCIZFVQDVPM-UHFFFAOYSA-N |
| Smiles | OC(C=C2)=CC=C2NC1=NC=CC=C1NS(C3=CC=C(OC)C=C3)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ABT 751
References for ABT 751
References are publications that support the biological activity of the product.
Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834 PMID: 16675578
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Citations for ABT 751
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets