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Submit ReviewAC 187
Description: Potent and selective amylin antagonist
Purity: ≥95% (HPLC)
Biological Activity for AC 187
AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
Technical Data for AC 187
| M. Wt | 2890.25 |
| Formula | C127H205N37O40 |
| Sequence |
VLGKLSQELHKLQTYPRTNTGSNTY (Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 151804-77-2 |
| PubChem ID | 16133792 |
| InChI Key | ZLFXHYNEZYAYPG-AABHONRUSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 187
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for AC 187
References for AC 187
References are publications that support the biological activity of the product.
Jhamandas and MacTavish (2004) Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J.Neurosci. 24 5579 PMID: 15201330
Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 137 121 PMID: 16914214
Reidelberger et al (2004) Amylin receptor blockade stimulates food intake in rats. Am.J.Physiol.Inter.Comp.Physiol. 287 R568
If you know of a relevant reference for AC 187, please let us know.
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Keywords: AC 187, AC 187 supplier, Potent, selective, amylin, receptors, antagonists, AC187, Calcitonin, and, Related, Receptors, 3419, Tocris Bioscience
3 Citations for AC 187
Citations are publications that use Tocris products. Selected citations for AC 187 include:
Liberini et al (2016) The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats. Mol Metab 5 834 PMID: 27688997
Baisley et al (2014) Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression. J Neurosci 34 4318 PMID: 24647952
Nuñez-Diaz et al (2023) Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. Mol Brain 16 25 PMID: 36793056
Do you know of a great paper that uses AC 187 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.