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Submit ReviewAC 253
Discontinued Product
6550 has been discontinued.
View all Calcitonin and Related Receptors products.
Description: Amylin (AMY3) antagonist
Biological Activity for AC 253
AC 253 is an amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.
Technical Data for AC 253
| M. Wt | 2847.11 |
| Formula | C122H196N40O39 |
| Sequence |
LGRLSQELHRLQTYPRTNTGSNTY (Modifications: Leu-1 = N-terminal Ac, Tyr-24 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 151804-79-4 |
| PubChem ID | 134160251 |
| InChI Key | QOVDFCPGVUGNIP-MLZIZKOLSA-N |
| Smiles | CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AC 253
References for AC 253
References are publications that support the biological activity of the product.
Coppock et al (1999) Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem.J. 338 15 PMID: 9931292
Jhamandas et al (2011) Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am.J.Pathol. 178 140 PMID: 21224052
Fu et al (2012) Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J,Biol.Chem. 287 18820 PMID: 22500019
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Keywords: AC 253, AC 253 supplier, AC253, amylin, receptor, antagonists, antagonism, neuroprotective, Abeta, amyloid, beta, AB, Aβ, Calcitonin, and, Related, Receptors, Amyloid, Beta, Peptides, 6550, Tocris Bioscience
Citations for AC 253
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Currently there are no citations for AC 253.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.