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AC 710

Cat. No. 5013 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PDGFR family inhibitor
Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AC 710

AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Compound Libraries for AC 710

AC 710 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 710

M. Wt 562.7
Formula C31H42N6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1351522-04-7
PubChem ID 54760053
InChI Key JVCWPUFNLFSKFS-UHFFFAOYSA-N
Smiles CC(C2)(C)N(CC)C(C)(C)CC2OC1=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AC 710

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.25 20

Preparing Stock Solutions for AC 710

The following data is based on the product molecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.89 mL 44.43 mL 88.86 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
2 mM 0.89 mL 4.44 mL 8.89 mL
10 mM 0.18 mL 0.89 mL 1.78 mL

Molarity Calculator

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References for AC 710

References are publications that support the biological activity of the product.

Liu et al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997 PMID: 24900421

If you know of a relevant reference for AC 710, please let us know.

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1 Citation for AC 710

Citations are publications that use Tocris products. Selected citations for AC 710 include:

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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