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Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Biological Activity for Ac2-12
Ac2-12 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
Technical Data for Ac2-12
| M. Wt | 1351.58 |
| Formula | C63H94N14O17S |
| Sequence |
AMVSEFLKQAW (Modifications: Ala-1 = N-terminal Ac) |
| Storage | Desiccate at -20°C |
| CAS Number | 256447-08-2 |
| PubChem ID | 90488718 |
| InChI Key | SUDAISORCUBKHK-RCVXMRHOSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ac2-12
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References for Ac2-12
References are publications that support the biological activity of the product.
Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735
Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373
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Keywords: Ac2-12, Ac2-12 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1846, Tocris Bioscience
Citations for Ac2-12
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