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Ac2-12

Cat. No. 1846 Submit a Review Datasheet / COA / SDS

Discontinued Product

1846 has been discontinued.

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Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for Ac2-12

Ac2-12 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Technical Data for Ac2-12

M. Wt 1351.58
Formula C63H94N14O17S
Sequence AMVSEFLKQAW

(Modifications: Ala-1 = N-terminal Ac)
Storage Desiccate at -20°C
CAS Number 256447-08-2
PubChem ID 90488718
InChI Key SUDAISORCUBKHK-RCVXMRHOSA-N
Smiles CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ac2-12

Certificate of Analysis / Product Datasheet
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References for Ac2-12

References are publications that support the biological activity of the product.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373

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Keywords: Ac2-12, Ac2-12 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1846, Tocris Bioscience

Citations for Ac2-12

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