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Description: Potent and selective ROCK2 inhibitor; orally bioavailable and brain penetrant
Chemical Name: (2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for CHDI 00580985
CHDI 00580985 is a potent and selective ROCK inhibitor (IC50 values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC50 = 4 nM). In vivo, CHDI 00580985 reduces ROCK signaling in Huntington's disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.
Licensing Information
Sold under license from CHDI Foundation
Technical Data for CHDI 00580985
| M. Wt | 372.44 |
| Formula | C20H25FN4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2573071-18-6 |
| PubChem ID | 155749520 |
| InChI Key | CIPXFTLGPVQJKN-HUUCEWRRSA-N |
| Smiles | FC1=CN=CC=C1N2C[C@H](N(CC2)C(N[C@@H](C3=CC(OC)=CC=C3)C)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHDI 00580985
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 | |
| ethanol | 37.24 | 100 |
Preparing Stock Solutions for CHDI 00580985
The following data is based on the product molecular weight 372.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for CHDI 00580985
References for CHDI 00580985
References are publications that support the biological activity of the product.
Ladduwahetty et al (2022) Identification of a potent, selective, and brain-penetrant Rho kinase inhibitor and its activity in a mouse model of Huntington's disease. J.Med.Chem. 65 9819 PMID: 35816678
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Citations for CHDI 00580985
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Literature in this Area
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