Ac2-26

Cat. No. 1845 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Purity: ≥95% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ac2-26

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

Technical Data for Ac2-26

M. Wt	3089.46
Formula	C₁₄₁H₂₁₀N₃₂O₄₄S
Sequence	AMVSEFLKQAWFIENEEQEYVQTVK (Modifications: Ala-1 = N-terminal Ac)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	151988-33-9
PubChem ID	16138723
InChI Key	ODWGEWZOPBDSHW-ISLQBSBZSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac2-26

Solubility

Soluble to 1 mg/ml in PBS

Product Datasheets for Ac2-26

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Ac2-26

References are publications that support the biological activity of the product.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306 PMID: 8409403

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854

Silistino-Souza et al (2007) Annexin 1: differential expression in tumor and mast cells in human larynx cancer Int.J.Cancer 120 2582 PMID: 17340616

Cardin et al (2019) Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis. FEBS Open Bio 9 668 PMID: 30984541

If you know of a relevant reference for Ac2-26, please let us know.

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Keywords: Ac2-26, Ac2-26 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1845, Tocris Bioscience