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Submit ReviewAcetaminophen
Description: Cyclooxygenase inhibitor; may be selective for COX-3
Alternative Names: Paracetamol
Chemical Name: N-(4-Hydroxyphenyl)acetamide
Purity: ≥99% (HPLC)
Biological Activity for Acetaminophen
Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
Compound Libraries for Acetaminophen
Acetaminophen is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Acetaminophen
| M. Wt | 151.16 |
| Formula | C8H9NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 103-90-2 |
| PubChem ID | 1983 |
| InChI Key | RZVAJINKPMORJF-UHFFFAOYSA-N |
| Smiles | CC(=O)NC1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Acetaminophen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 15.12 | 100 | |
| DMSO | 15.12 | 100 |
Preparing Stock Solutions for Acetaminophen
The following data is based on the product molecular weight 151.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.62 mL | 33.08 mL | 66.16 mL |
| 5 mM | 1.32 mL | 6.62 mL | 13.23 mL |
| 10 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 50 mM | 0.13 mL | 0.66 mL | 1.32 mL |
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Product Datasheets for Acetaminophen
References for Acetaminophen
References are publications that support the biological activity of the product.
Chandrasekharan et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 99 13926 PMID: 12242329
Chong et al (2001) Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 35 1476 PMID: 11724102
Riendeau et al (1997) Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 75 1088 PMID: 9365818
If you know of a relevant reference for Acetaminophen, please let us know.
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Keywords: Acetaminophen, Acetaminophen supplier, Cyclooxygenase, inhibitors, inhibits, COX-3, Oxygenases, Oxidases, Paracetamol, 1706, Tocris Bioscience
3 Citations for Acetaminophen
Citations are publications that use Tocris products. Selected citations for Acetaminophen include:
Inagaki et al (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci 13 13 PMID: 23137391
Liu and Gao (2007) Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol 97 837 PMID: 17093123
Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 104 4083 PMID: 17360481
Do you know of a great paper that uses Acetaminophen from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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