Home / Pharmacology / GPCRs / 7-TM Receptors / Orphan 7-TM Receptors / Orphan 7-TM Receptor Inverse Agonists / AF 64394

AF 64394

Cat. No. 6931 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective GPR3 inverse agonist
Chemical Name: N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AF 64394

AF 64394 is a potent and selective GPR3 inverse agonist (pIC50 = 7.3). Selective for GPR3 over GPR6 and GPR12 (pIC50 values are 5.1 and 4.9, respectively).

Compound Libraries for AF 64394

AF 64394 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AF 64394

M. Wt 393.87
Formula C21H20ClN5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1637300-25-4
PubChem ID 125286314
InChI Key WBYNZQXAAWPAGR-UHFFFAOYSA-N
Smiles CC(C)OC1=C(CNC2=CC(=NC3=NC=NN23)C2=CC=CC=C2)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AF 64394

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.39 100

Preparing Stock Solutions for AF 64394

The following data is based on the product molecular weight 393.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for AF 64394

References are publications that support the biological activity of the product.

Jensen et al (2014) The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg.Med.Chem.Lett. 24 5195 PMID: 25442311

Godlewski et al (2015) Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue. Sci.Rep. 5 14953 PMID: 26455425

If you know of a relevant reference for AF 64394, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Orphan 7-TM Receptor Inverse Agonists

Keywords: AF 64394, AF 64394 supplier, AF64394, Potent, selective, GPR3, inverse, agonists, agonism, obesity, Orphan, 7-TM, Receptors, 6931, Tocris Bioscience

Citations for AF 64394

Citations are publications that use Tocris products.

Currently there are no citations for AF 64394. Do you know of a great paper that uses AF 64394 from Tocris? Please let us know.

Reviews for AF 64394

There are currently no reviews for this product. Be the first to review AF 64394 and earn rewards!

Have you used AF 64394?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review