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Submit Review[Ala17]-MCH
Discontinued Product
3434 has been discontinued.
View all Melanin-concentrating Hormone Receptors products.
Description: Potent MCH receptor agonist
Biological Activity for [Ala17]-MCH
[Ala17]-MCH is a potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
Technical Data for [Ala17]-MCH
| M. Wt | 2271.71 |
| Formula | C97H155N29O26S4 |
| Sequence |
DFDMLRCMLGRVYRPCAQV (Modifications: Disulfide bridge between 7 - 16) |
| Storage | Store at -20°C |
| CAS Number | 359784-84-2 |
| PubChem ID | 90488845 |
| InChI Key | IVEALEKXBDDRGB-UKPWUPKZSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Ala17]-MCH
References for [Ala17]-MCH
References are publications that support the biological activity of the product.
Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID: 11478907
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal.Biochem. 328 187 PMID: 15113696
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Keywords: [Ala17]-MCH, [Ala17]-MCH supplier, Potent, MCH, receptors, agonists, Melanin-concentrating, Hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Receptors, 3434, Tocris Bioscience
1 Citation for [Ala17]-MCH
Citations are publications that use Tocris products. Selected citations for [Ala17]-MCH include:
Camp et al (2016) Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res 105 13 PMID: 26773201
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