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Submit ReviewAlantolactone
Description: Antiproliferative; induces activin/Smad3 signaling
Chemical Name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Purity: ≥98% (HPLC)
Biological Activity for Alantolactone
Alantolactone is a sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.
Technical Data for Alantolactone
| M. Wt | 232.32 |
| Formula | C15H20O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 546-43-0 |
| PubChem ID | 72724 |
| InChI Key | PXOYOCNNSUAQNS-AGNJHWRGSA-N |
| Smiles | O=C3C([C@@]2([H])C=C1[C@@H](C)CCC[C@@](C)1C[C@]([H])2O3)=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Alantolactone
References for Alantolactone
References are publications that support the biological activity of the product.
Dupuis & Brisson et al (1976) Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 15 205 PMID: 1000726
Shi et al (2011) Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and AVNreceptor type II A in AVNsignaling pathway. J.Biomol.Screen. 16 525 PMID: 21378277
Pal et al (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 24 1599 PMID: 20600805
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Keywords: Alantolactone, Alantolactone supplier, antiproliferative, sesquiterpene, lactones, activin, SMAD3, type, II, A, receptors, BMP, and, Other, Activin, Receptors, 4490, Tocris Bioscience
Citations for Alantolactone
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Currently there are no citations for Alantolactone.
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Stem Cell Research Product Guide
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Pathways for Alantolactone
