Home / Pharmacology / Enzymes / Phosphatases / Protein Tyrosine Phosphatases / Protein Tyrosine Phosphatases Inhibitors / Alexidine dihydrochloride

Alexidine dihydrochloride

Cat. No. 3979 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective inhibitor of PTPMT1
Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride
Datasheet
Citations (1)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Alexidine dihydrochloride

Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Compound Libraries for Alexidine dihydrochloride

Alexidine dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Alexidine dihydrochloride

M. Wt 581.71
Formula C26H56N10.2HCl
Storage Desiccate at -20°C
CAS Number 1715-30-6
PubChem ID 102678
InChI Key BRJJFBHTDVWTCJ-UHFFFAOYSA-N
Smiles N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Alexidine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.17 100
ethanol 58.17 100

Preparing Stock Solutions for Alexidine dihydrochloride

The following data is based on the product molecular weight 581.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.6 mL 17.19 mL
5 mM 0.34 mL 1.72 mL 3.44 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for Alexidine dihydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Alexidine dihydrochloride

References are publications that support the biological activity of the product.

Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234 PMID: 16985057

Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584 PMID: 20167843

Liu et al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562 PMID: 25593337

If you know of a relevant reference for Alexidine dihydrochloride, please let us know.

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1 Citation for Alexidine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Alexidine dihydrochloride include:

Niemi et al (2013) Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One 8 e53803 PMID: 23326511

Do you know of a great paper that uses Alexidine dihydrochloride from Tocris? Please let us know.

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