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Description: TRPC5 inhibitor
Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Purity: ≥97% (HPLC)
Biological Activity for AM 12
AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.
Technical Data for AM 12
| M. Wt | 349.14 |
| Formula | C15H9BrO5 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 2387510-84-9 |
| PubChem ID | 137553166 |
| InChI Key | OVIAJBSVWWYJSD-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AM 12
References for AM 12
References are publications that support the biological activity of the product.
Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375
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Keywords: AM 12, AM 12 supplier, AM12, canonical, transient, receptor, potential, channels, inhibitors, inhibits, TRPC5, TRPC, 6495, Tocris Bioscience
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