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Submit ReviewAM 4113
Description: High affinity and selective CB1 antagonist
Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for AM 4113
AM 4113 is a high affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.
Compound Libraries for AM 4113
AM 4113 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AM 4113
| M. Wt | 380.66 |
| Formula | C17H12Cl3N3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 614726-85-1 |
| PubChem ID | 66844170 |
| InChI Key | BBUKVPCUOHFAQN-UHFFFAOYSA-N |
| Smiles | CC1=C(C2=CC=C(C=C2)Cl)N(C3=C(C=C(C=C3)Cl)Cl)N=C1C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 4113
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.61 | 20 | |
| ethanol | 7.61 | 20 |
Preparing Stock Solutions for AM 4113
The following data is based on the product molecular weight 380.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.14 mL | 65.68 mL | 131.35 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.27 mL |
| 2 mM | 1.31 mL | 6.57 mL | 13.14 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
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Product Datasheets for AM 4113
References for AM 4113
References are publications that support the biological activity of the product.
Sink et al (2008) The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33 946 PMID: 17581535
Hodge et al (2008) The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 193 298 PMID: 18602425
If you know of a relevant reference for AM 4113, please let us know.
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Keywords: AM 4113, AM 4113 supplier, AM4113, high, affinity, selective, CB1, antagonists, Cannabinoids, Receptors, cb1r, 6193, Tocris Bioscience
Citations for AM 4113
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Literature in this Area
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