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Submit ReviewAM 6545
Description: High affinity and selective CB1 antagonist
Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for AM 6545
AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.
Compound Libraries for AM 6545
AM 6545 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AM 6545
| M. Wt | 556.46 |
| Formula | C26H23Cl2N5O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1245626-05-4 |
| PubChem ID | 46912919 |
| InChI Key | XBHQLFVDGLPBCK-UHFFFAOYSA-N |
| Smiles | O=C(NN3CCS(CC3)(=O)=O)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(C#CCCC#N)C=C4)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 6545
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.13 | 20 |
Preparing Stock Solutions for AM 6545
The following data is based on the product molecular weight 556.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.99 mL | 44.93 mL | 89.85 mL |
| 1 mM | 1.8 mL | 8.99 mL | 17.97 mL |
| 2 mM | 0.9 mL | 4.49 mL | 8.99 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
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Product Datasheets for AM 6545
References for AM 6545
References are publications that support the biological activity of the product.
Tam et al (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J.Clin.Invest. 120 2953 PMID: 20664173
Bowles et al (2015) A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc.Natl.Acad.Sci.U.S.A. 112 285 PMID: 25535367
If you know of a relevant reference for AM 6545, please let us know.
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Keywords: AM 6545, AM 6545 supplier, AM6545, CB1, receptors, antagonists, high, affinity, selective, obesity, lipids, glucose, Receptors, 5443, Tocris Bioscience
1 Citation for AM 6545
Citations are publications that use Tocris products. Selected citations for AM 6545 include:
Giulio G et al (2022) Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Mol Psychiatry 27 2340-2354 PMID: 35075269
Do you know of a great paper that uses AM 6545 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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