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AMBMP hydrochloride

Cat. No. 6043 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Wnt canonical signaling activator; also tubulin polymerization inhibitor
Alternative Names: BML 284,CID 11210285
Chemical Name: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AMBMP hydrochloride

AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.

Technical Data for AMBMP hydrochloride

M. Wt 386.84
Formula C19H18N4O3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2095432-75-8
PubChem ID 122705993
InChI Key XZOFNDFDGVAIEH-UHFFFAOYSA-N
Smiles COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMBMP hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.68 100

Preparing Stock Solutions for AMBMP hydrochloride

The following data is based on the product molecular weight 386.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.93 mL 25.85 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for AMBMP hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for AMBMP hydrochloride

References are publications that support the biological activity of the product.

Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID: 15724259

Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID: 26613980

Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID: 27207629

Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID: 23405280

If you know of a relevant reference for AMBMP hydrochloride, please let us know.

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1 Citation for AMBMP hydrochloride

Citations are publications that use Tocris products. Selected citations for AMBMP hydrochloride include:

Vadivel et al (2020) SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Biochem J 477 1409-1425 PMID: 32219372

Do you know of a great paper that uses AMBMP hydrochloride from Tocris? Please let us know.

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Pathways for AMBMP hydrochloride

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.