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Submit ReviewAmbuic Acid
Description: Quorum sensing inhibitor; antibacterial
Chemical Name: (2E)-4-[(1R,5R,6R)-3-(1E)-1-Hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid
Purity: ≥95% (HPLC)
Biological Activity for Ambuic Acid
Quorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.
Technical Data for Ambuic Acid
| M. Wt | 350.41 |
| Formula | C19H26O6 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 340774-69-8 |
| PubChem ID | 11152290 |
| InChI Key | UDSQZJMGPSRCEM-HDKVZZTHSA-N |
| Smiles | CCCCC/C=C/C1=C([C@H]([C@H]2O[C@]2(C1=O)C/C=C(C(O)=O)\C)O)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ambuic Acid
References for Ambuic Acid
References are publications that support the biological activity of the product.
Todd et al (2017) Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections. Antimicrob.Agents Chemother. 61 e00263-17 PMID: 28607020
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Keywords: Ambuic Acid, Ambuic Acid supplier, quorum, sensing, inhibitors, inhibits, antibacterial, auto-inducing, peptide, AIP, signal, biosynthesis, MRSA, methicillin, meticillin, resistant, Staphylococcus, aureus, Antibiotics, 6547, Tocris Bioscience
Citations for Ambuic Acid
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