Home / Pharmacology / Enzymes / Kinases / MAPK Family / p38 MAPK / p38 MAPK Inhibitors / AMG 548

AMG 548

Cat. No. 3920 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective p38α inhibitor
Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AMG 548

AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.

Compound Libraries for AMG 548

AMG 548 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AMG 548

M. Wt 461.56
Formula C29H27N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 864249-60-5
PubChem ID 11167112
InChI Key RQVKVJIRFKVPBF-VWLOTQADSA-N
Smiles O=C1N(C)C(NC[C@@H](N)CC5=CC=CC=C5)=NC(C4=CC=NC=C4)=C1C3=CC2=C(C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMG 548

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.8 100
ethanol 49.8 100

Preparing Stock Solutions for AMG 548

The following data is based on the product molecular weight 461.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for AMG 548

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AMG 548

References are publications that support the biological activity of the product.

Dominguez et al (2005) p38 MAP kinase inhibitors: many are made, but few are chosen. Curr.Opin.Drug Discov.Devel. 8 421 PMID: 16022178

Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979 PMID: 16378500

If you know of a relevant reference for AMG 548, please let us know.

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Keywords: AMG 548, AMG 548 supplier, AMG548, potent, selective, p38alpha, p38a, p38α, inhibitors, inhibits, p38, 3920, Tocris Bioscience

3 Citations for AMG 548

Citations are publications that use Tocris products. Selected citations for AMG 548 include:

Rozbeh et al (2014) The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc 9 2100-22 PMID: 25101824

Kai et al (2022) Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses. Int J Mol Sci 23 PMID: 35628420

Eckle et al (2013) HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. J Biol Chem 11 e1001665 PMID: 24086109

Do you know of a great paper that uses AMG 548 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for AMG 548

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.