Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAminopurvalanol A
Description: Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 97
Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity: ≥98% (HPLC)
Biological Activity for Aminopurvalanol A
Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 >100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.
Licensing Information
Sold under license from the Regents of the University of California
Compound Libraries for Aminopurvalanol A
Aminopurvalanol A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for Aminopurvalanol A
| M. Wt | 403.91 |
| Formula | C19H26ClN7O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 220792-57-4 |
| PubChem ID | 6604931 |
| InChI Key | RAMROQQYRRQPDL-HNNXBMFYSA-N |
| Smiles | ClC1=CC(N)=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Aminopurvalanol A
References for Aminopurvalanol A
References are publications that support the biological activity of the product.
Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 6 361 PMID: 10375538
Knockaert et al (2000) Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 7 411 PMID: 10873834
Rosiana et al (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA 96 4797
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
View Related Products by Target
View Related Products by Product Action
Keywords: Aminopurvalanol A, Aminopurvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, AminopurvalanolA, NG97, NG, 97, Kinase, Non-selective, CDKs, 2072, Tocris Bioscience
1 Citation for Aminopurvalanol A
Citations are publications that use Tocris products. Selected citations for Aminopurvalanol A include:
Teo et al (2006) An evolutionary conserved role of Wnt signaling in stem cell fate decision. Dev Biol 289 91 PMID: 16309665
Reviews for Aminopurvalanol A
There are currently no reviews for this product. Be the first to review Aminopurvalanol A and earn rewards!
Have you used Aminopurvalanol A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image