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Submit ReviewAmyloid β-Peptide (1-42) (human)
Description: Predominant amyloid β-protein fragment
Purity: ≥95% (HPLC)
Biological Activity for Amyloid β-Peptide (1-42) (human)
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.
Control Peptide also available.
Technical Data for Amyloid β-Peptide (1-42) (human)
| M. Wt | 4514.08 |
| Formula | C203H311N55O60S |
| Sequence | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 107761-42-2 |
| PubChem ID | 16135558 |
| InChI Key | DZHSAHHDTRWUTF-SIQRNXPUSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Amyloid β-Peptide (1-42) (human)
| Solubility | Soluble to 1 mg/ml in 50mM Tris buffer |
Product Datasheets for Amyloid β-Peptide (1-42) (human)
References for Amyloid β-Peptide (1-42) (human)
References are publications that support the biological activity of the product.
Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 120 885 PMID: 6375662
Paradis et al (1996) Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 16 7533 PMID: 8922409
Van Nostrand et al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297 PMID: 8624102
If you know of a relevant reference for Amyloid β-Peptide (1-42) (human), please let us know.
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Keywords: Amyloid beta-peptide (1-42) (human), Amyloid beta-peptide (1-42) (human) supplier, amyloid, β-protein, beta-protein, fragment, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, Peptides, Amyloid, β-peptide, beta-peptide, (1-42), (human), amyloidbeta, amyloidb, amyloidβ, Beta, 1428, Tocris Bioscience
6 Citations for Amyloid β-Peptide (1-42) (human)
Citations are publications that use Tocris products. Selected citations for Amyloid β-Peptide (1-42) (human) include:
Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neuroinflammation 10 e0117555 PMID: 25689857
Hui et al (2016) Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PLoS One 11 e0147134 PMID: 26788729
Scuderi et al (2012) Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α. Dent Res J (Isfahan) 9 49 PMID: 22405189
Deléglise et al (2014) β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network. Acta Neuropathol Commun 2 145 PMID: 25253021
Chen and Chai (2019) Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28. BMC Res Notes 12 5 PMID: 30606244
Mouchard et al (2019) ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease. Sci Rep 9 3989 PMID: 30850702
Do you know of a great paper that uses Amyloid β-Peptide (1-42) (human) from Tocris? Please let us know.
Reviews for Amyloid β-Peptide (1-42) (human)
Average Rating: 5 (Based on 1 Review.)
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Great product for inflammation testing..
By
Eric Dyne on 09/24/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Microglia
I used this peptide to induce aggregation along with several other brands. The tocris beta-amyloid reacted the best with Thioflavin-T (1uM) in my experience however, I did find the bachem sample seemed to have the best aggregation patterns.
I used a stationary incubator at 30C and a mixture in an upcoming manuscript that promoted optimal aggregation that was reproducible. I did not use DMSO or water but a special phosphate buffer with alkaline solution.
Literature in this Area
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.